John J P Kastelein Selected Research

dalcetrapib

12/2014	Treatment of low HDL-C subjects with the CETP modulator dalcetrapib increases plasma campesterol only in those without ABCA1 and/or ApoA1 mutations.
4/2012	Vascular effects and safety of dalcetrapib in patients with or at risk of coronary heart disease: the dal-VESSEL randomized clinical trial.
1/2011	Rationale and design of dal-VESSEL: a study to assess the safety and efficacy of dalcetrapib on endothelial function using brachial artery flow-mediated vasodilatation.
7/2009	Safety and tolerability of dalcetrapib.
5/2005	Effectiveness of inhibition of cholesteryl ester transfer protein by JTT-705 in combination with pravastatin in type II dyslipidemia.
5/2002	Efficacy and safety of a novel cholesteryl ester transfer protein inhibitor, JTT-705, in humans: a randomized phase II dose-response study.

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John J P Kastelein Research Topics

Disease

122	Cardiovascular Diseases (Cardiovascular Disease) 11/2022 - 01/2002
107	Hyperlipoproteinemia Type II (Familial Hypercholesterolemia) 01/2022 - 07/2002
76	Coronary Artery Disease (Coronary Atherosclerosis) 01/2021 - 05/2002
75	Atherosclerosis 01/2021 - 01/2002
62	Coronary Disease (Coronary Heart Disease) 01/2019 - 04/2002
40	Myocardial Infarction 01/2021 - 12/2002
24	Inflammation (Inflammations) 04/2022 - 12/2002
22	Hypercholesterolemia 09/2020 - 10/2003
21	Stroke (Strokes) 01/2019 - 04/2005
20	Dyslipidemias (Dyslipidemia) 12/2020 - 10/2004
17	Atherosclerotic Plaque (Atheroma) 01/2021 - 02/2006
17	Hypertension (High Blood Pressure) 07/2018 - 06/2004
13	Neoplasms (Cancer) 01/2019 - 09/2004
12	Homozygous Familial Hypercholesterolemia 05/2022 - 03/2014
12	Metabolic Syndrome (Dysmetabolic Syndrome X) 03/2013 - 04/2005
11	Injection Site Reaction 09/2020 - 08/2007
11	Vascular Diseases (Vascular Disease) 11/2016 - 12/2002
10	Hypertriglyceridemia 01/2022 - 09/2004
10	Hyperlipidemias (Hyperlipidemia) 01/2022 - 02/2002
10	Type 2 Diabetes Mellitus (MODY) 05/2021 - 12/2004
10	Acute Coronary Syndrome 01/2019 - 04/2005
10	Diabetes Mellitus 01/2018 - 11/2005
10	Carotid Artery Diseases 12/2013 - 05/2003
9	Unstable Angina 01/2019 - 11/2008
8	Insulin Resistance 11/2022 - 07/2007
7	Hypoalphalipoproteinemias (Hypoalphalipoproteinemia) 12/2014 - 10/2002
6	Body Weight (Weight, Body) 01/2020 - 05/2007
6	Inborn Genetic Diseases (Disease, Hereditary) 01/2019 - 04/2005
6	Heart Failure 12/2015 - 02/2007
5	Pancreatitis 12/2019 - 09/2004
5	Hypotension (Low Blood Pressure) 11/2016 - 04/2005
5	Abdominal Obesity 07/2011 - 01/2008
4	Chronic Renal Insufficiency 01/2019 - 12/2006
4	Infections 01/2017 - 10/2004
4	Heart Arrest (Cardiac Arrest) 04/2012 - 04/2005

Drug/Important Bio-Agent (IBA)

122	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2021 - 07/2002
98	LDL CholesterolIBA 11/2022 - 04/2002
91	LipidsIBA 04/2022 - 10/2002
75	oxidized low density lipoproteinIBA 11/2022 - 04/2002
65	HDL CholesterolIBA 11/2022 - 05/2002
46	CholesterolIBA 01/2022 - 01/2002
36	Lipoproteins (Lipoprotein)IBA 01/2019 - 08/2002
35	Atorvastatin (Lipitor)FDA Link 01/2019 - 12/2002
28	Triglycerides (Triacylglycerol)IBA 01/2019 - 06/2004
28	ApolipoproteinsIBA 03/2018 - 06/2003
27	Apolipoproteins B (ApoB)IBA 11/2022 - 10/2003
25	LDL Lipoproteins (beta Lipoproteins)IBA 01/2020 - 10/2003
24	Apolipoprotein A-I (Apolipoprotein A1)IBA 01/2021 - 10/2004
24	Biomarkers (Surrogate Marker)IBA 01/2016 - 12/2002
23	Simvastatin (Zocor)FDA LinkGeneric 03/2013 - 07/2002
22	C-Reactive ProteinIBA 01/2019 - 12/2002
19	HDL LipoproteinsIBA 01/2018 - 08/2004
18	Cholesterol Ester Transfer ProteinsIBA 09/2022 - 01/2003
18	LDL Receptors (LDL Receptor)IBA 01/2019 - 12/2002
15	Pravastatin (Pravachol)FDA LinkGeneric 10/2019 - 05/2003
12	Ezetimibe (Zetia)FDA Link 01/2021 - 02/2005
12	alirocumabIBA 09/2020 - 06/2014
12	Rosuvastatin Calcium (Crestor)FDA Link 01/2018 - 03/2003
12	Trinitrotoluene (TNT)IBA 11/2016 - 09/2006
11	Proprotein Convertase 9IBA 01/2021 - 06/2014
9	mipomersenIBA 01/2021 - 05/2010
9	Lipoprotein Lipase (Diacylglycerol Lipase)IBA 01/2019 - 09/2004
8	Glucose (Dextrose)FDA LinkGeneric 11/2022 - 06/2004
8	Proteins (Proteins, Gene)FDA Link 01/2021 - 10/2003
7	Pharmaceutical PreparationsIBA 01/2020 - 02/2004
7	torcetrapibIBA 11/2012 - 04/2007
6	EnzymesIBA 04/2022 - 06/2006
6	dalcetrapibIBA 12/2014 - 05/2002
5	Insulin (Novolin)FDA Link 09/2022 - 09/2009
5	Lipoprotein(a)IBA 01/2022 - 06/2004
5	DNA (Deoxyribonucleic Acid)IBA 08/2017 - 05/2004
5	Secretory Phospholipases A2IBA 01/2014 - 04/2005
5	AdiponectinIBA 01/2012 - 01/2008
5	Adenosine Triphosphate (ATP)IBA 10/2011 - 10/2002
4	ALN-PCSIBA 01/2021 - 01/2017
4	CSL112IBA 01/2021 - 10/2016
4	evolocumabIBA 10/2020 - 06/2016
4	Monoclonal AntibodiesIBA 01/2020 - 06/2014
4	bococizumabIBA 07/2018 - 08/2016
4	CER-001IBA 01/2018 - 12/2014
4	lipoprotein cholesterolIBA 11/2016 - 04/2005
4	Phytosterols (Plant Sterols)IBA 12/2014 - 12/2005
4	Aryldialkylphosphatase (Paraoxonase)IBA 08/2009 - 02/2005
3	Eicosapentaenoic AcidIBA 04/2022 - 01/2014
3	Fatty Acids (Saturated Fatty Acids)IBA 04/2022 - 01/2016
3	icosabutateIBA 04/2022 - 01/2016
3	Nonesterified Fatty Acids (NEFA)IBA 01/2022 - 01/2012
3	BMS201038IBA 01/2021 - 03/2014
3	Phospholipids (Phosphatides)FDA LinkGeneric 11/2020 - 05/2006
3	CreatinineIBA 01/2019 - 12/2006
3	omega-Chloroacetophenone (Mace)IBA 01/2019 - 12/2015
3	varespladibIBA 01/2019 - 04/2011
3	Apolipoprotein C-IIIIBA 11/2018 - 07/2015

Therapy/Procedure

94	Therapeutics 09/2022 - 08/2002
10	Secondary Prevention 01/2021 - 11/2005
5	Resuscitation 06/2013 - 04/2005
4	Drug Therapy (Chemotherapy) 01/2021 - 06/2004
4	Subcutaneous Injections 01/2021 - 12/2016
3	Blood Component Removal (Apheresis) 01/2021 - 10/2014
3	Intravenous Infusions 01/2020 - 01/2018